1st Round giant killers Standard Liege and River Plate have been ‘rewarded’ with tough away ties at former winners Atletico Madrid and Manchester City, respectively.
Villarreal, who knocked out Borussia Dortmund, land an easier looking home fixture against Rubin Kazan.
Two former winners Bayer Leverkusen and Flamengo meet in what could be the tie of the round.
Fixtures are one leg only, to be played on Saturday 14 March.
| Bayer Leverkusen | – | Flamengo | ||
| FK Partizan | – | ACF Fiorentina | ||
| FC Augsburg | – | Paris Saint-Germain | ||
| Sunderland | – | Stoke City | ||
| SSC Napoli | – | Dynamo Moskva | ||
| Rubin Kazan | – | Villarreal | ||
| Chelsea | – | Ajax | ||
| Manchester City | – | River Plate | ||
| Atletico Madrid | – | Standard Liege | ||
| Newcastle United | – | SL Benfica | ||
| FC Schalke 04 | – | Levante | ||
| Aston Villa | – | Zenit Saint Petersburg | ||
| Hellas Verona | – | Werder Bremen | ||
| AS Roma | – | Spartak Moskva | ||
| RSC Anderlecht | – | Galatasaray | ||
| FC Porto | – | Lokomotiv Moskva |
Top 100 